Results of this approach were different depending from single clinical studies.In early studies results were positive for the magnitude of systolic blood pressure reduction while in later studies, when sham-controlled trials were performed, were negative.
We conducted a systematic review approved by Hypertension cochrane to assess short and long-term effects of renal denervation on clinical endpoints: Cardiovascular events, Hospitalization, Quality of life, complications related to procedure.
In conclusion our review demonstrated that renal denervation results, until now, are not sufficient to support its use in clinical. Benefits on Hard Outcomes are inconclusive.
Renal Denervation is a safe procedure.
For the future we need trials with longer follow-up periods and larger populations. The use of catheter with multi-electrodes able to reach and treat nerves without the empiric approach emerged with current technologies could help to improve the use of renal denervation for hypertension.
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