COMPARISON OF ANTIOXIDANT AND OXIDATIVE STRESS MARKERS IN DIALYSIS MODIALITIES FOR PATIENTS WITH CHRONIC KIDNEY DISEASE

/ 53° Congresso nazionale / Di
Dialisi peritoneale

COMPARISON OF ANTIOXIDANT AND OXIDATIVE STRESS MARKERS IN DIALYSIS MODIALITIES FOR PATIENTS WITH CHRONIC KIDNEY DISEASE

comunicazione

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Introduction

Reactive oxygen species (ROS) are involved in unleashing and aggravating various human pathologies. The association between non-enzymatic antioxidative capacity and serum levels of oxidative stress markers (advanced oxidation protein products, lipoperoxidation, reduction in thiol groups) are a good measure of an organism’s oxidative status. It is known that in end stage renal disease (ESRD) oxidative stress increases, but there is no conclusive information concerning differences between hemodialysis and peritoneal dialysis.

 

Objetive

In this work, we compared the antioxidative and oxidative stress capacity of plasma in ESRD patients under dialysis treatment in two modalities: peritoneal dialysis (PD) and hemodialysis (HD), compared against apparently healthy controls.

 

Patients and healthy subjects

617 patients with ESRD

  • 195 patients CAPD
  • 114 patients APD
  • 308 patients HD

 

205 healthy subjects

 

Biochemical determinations

Pro-oxidants

  • Advanced glycation products (AGE)
  • Malondialdehyde (MDA)
  • Advanced oxidation protein products (AOPP)
  • Total carbonyls (-COH, -CO-)

 

Antioxidants

  • Vitamin C (VC)
  • Total glutation (-SH)
  • Superoxide of dismutase (SOD)

 

Others

  • Nitric oxide(NOx)

 

Results 1

See figure 2 and 3

 

Conclusions

  1. Patients on PD have less AGEs, MDA, AOPP, and more Vitamin C and glutation when compared with patients on HD.
  2. Our data indicate that not all markers of oxidative stress behave equally, since they can be modified by various conditions within the same group of subjects.
  3. We did not find significant differences in the other markers (total carbonyls, SOD and NOx).
  4. Our data suggest that patients with ESRD in HD treatment are subjected to greater oxidative stress compared with those on PD.

 

Acknowledgements

This study was supported by the Consejo Nacional de Ciencia y Tecnología (CONACyT) No. 115403, and Instituto Mexicano del Seguro Social granted to JMG.

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