Estimation of peritoneal membrane transport characteristics from peritoneal clearance measurements

Introduction and Aim

Regular measurement of Kt/V and creatinine clearance is suggested in peritoneal dialysis (PD) in order to document sufficient depuration. Peritoneal membrane transport status by a peritoneal equilibration test (PET) test is carried out less frequently. The aim of the study is to estimate the membrane transport status from peritoneal clearance measurements.

Patients and Methods

D/P creatinine was calculated from PET and from peritoneal clearance measurements in patients under automated PD (APD: 244 measurements in 125 patients, patient age median 65 years) and continuous ambulatory PD (CAPD: 84 measurements in 45 patients, patient age median 73 years). APD patients presented 24-hour dialysate volume from 7535 ml to 28416 ml (median 15000ml) whereas CAPD patients respectively from 4900 ml to 15000 ml (median 8500 ml). Correlation matrices between D/P creatinine from PET versus peritoneal clearance measurements were elaborated for both PD modalities.


D/P creatinine from peritoneal clearance measurements correlated significantly to D/P creatinine from PET (APD: r=0.62, p<0.001; CAPD: r=0.62, p<0.001). Patients with fast peritoneal membrane transport type in PET presented significantly higher D/P creatinine in peritoneal clearance measurements in confront to patients with slow transport type in PET.


Peritoneal transport status can be estimated from peritoneal clearance measurements in APD and CAPD. From a clinical viewpoint, the calculation of D/P creatinine from peritoneal clearance measurements might be helpful to distinguish between fast and slow peritoneal membrane transport status, even without having previously performed a PET.